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In patients with epilepsy.Lariam (mefloquine) may increase the risk of convulsions. The drug should therefore be prescribed only for curative treatment in such patients and only if there are compelling medical reasons for its use (see PRECAUTIONS. DRUG INTERACTIONS ).

Concomitant administration of Lariam and quinine or quinidine may produce electrocardiographic abnormalities.

But Roche did know something about Lariam and suicide. Over the past year.two UPI reporters.Dan Olmsted and Mark Benjamin.unearthed internal documents. They show that by the time Chuck Perry killed himself.the company knew of at least seven suicides.and 13 suicide attempts.by people living outside the United States – all associated with Lariam. But nowhere in its product information was there any mention of the word suicide.

Malaria can cause confusion.coma.and seizures. It can cause kidney failure.breathing problems.and severe damage to red blood cells.

Periodic evaluation of hepatic function should be performed during prolonged prophylaxis.

In patients taking an anticonvulsant (eg.valproic acid.carbamazepine.phenobarbital or phenytoin).the concomitant use of Lariam (mefloquine) may reduce seizure control by lowering the plasma levels of the anticonvulsant. Therefore.patients concurrently taking antiseizuremedication and Lariam (mefloquine) should have the blood level of their antiseizure medication monitored and the dosage adjusted appropriately (see PRECAUTIONS ).

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lariam administered to pregnant mice, rats, and rabbits was teratogenic at doses similar to the clinical acute treatment dose of 21 to 25 mg kg, based on body surface area comparisons.